Lateralized Expression of Cortical Perineuronal Nets during Maternal Experience is Dependent on MECP2

摘要: Cortical neuronal circuits along the sensorimotor pathways are shaped by experience during critical periods of heightened plasticity in early postnatal development. After closure periods, measured histologically formation and maintenance extracellular matrix structures called perineuronal nets (PNNs), adult mouse brain exhibits restricted maturity. Mature PNNs typically considered to be stable that restrict synaptic on cortical parvalbumin+ (PV+) GABAergic neurons. Changes environment (i.e., novel behavioral training) or social contexts motherhood) known elicit relevant neural circuitry. However, little is about concomitant changes surrounding PV+ Here, we show PNN density primary somatosensory cortex (SS1) female mice after maternal [called surrogate (Sur)], using systematic microscopy analysis a whole region. On average, were increased right barrel field decreased left forelimb regions. Individual had hemisphere dominance density. Using deficient methyl-CpG-binding protein 2 (MECP2), an epigenetic regulator involved regulating experience-dependent plasticity, found MECP2 for this precise dynamic expression PNN. Adult naive Mecp2-heterozygous (Het) females specific subregions both hemispheres before experience, compared with wild-type (WT) littermate controls. The laterality seen Het (NH) was lost Sur (SH) mice, suggesting possible intact mechanisms plasticity. Together, our results identify subregion hemisphere-specific alterations females, as neurobiological mechanism behaviors rodents.