Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption

摘要: More than 25 years have passed since it was first recognized that bisphosphonates could inhibit bone resorption.1–3 During this time, become the treatment of choice for a variety diseases in which excessive osteoclast activity is an important pathological feature, including Paget’s disease bone,4 metastatic and osteolytic disease, hypercalcemia malignancy5 and, more recently, postmenopausal other forms osteoporosis (Fig. 7.1).6,7 However, despite widespread clinical use bisphosphonates, their exact mechanism action, at both cellular molecular level, not been clearly identified.