Intranasally and orally active GH secretagogues are useful clinical tools: so why are they not on the market?

作者: Zvi Laron

DOI: 10.1007/BF03345130

关键词: Oral administrationOrally activeMedicineGh secretagoguesNasal administrationEndocrinologyInternal medicine

摘要:

参考文章(18)
Zvi Laron, Jenny Frenkel, Aviva Silbergeld, Growth Hormone Releasing Peptide—Hexarelin—in Children: Biochemical and Growth Promoting Effects Springer, New York, NY. pp. 379- 387 ,(1996) , 10.1007/978-1-4612-2396-2_24
M. Gasperi, G. Aimaretti, G. Scarcello, G. Corneli, C. Cosci, E. Arvat, E. Martino, E. Ghigo, Low dose hexarelin and growth hormone (GH)-releasing hormone as a diagnostic tool for the diagnosis of GH deficiency in adults: comparison with insulin-induced hypoglycemia test. The Journal of Clinical Endocrinology and Metabolism. ,vol. 84, pp. 2633- 2637 ,(1999) , 10.1210/JCEM.84.8.5904
V. Sibilia, D. Cocchi, F. Pagani, N. Lattuada, G.L. Moro, A. Pecile, A. Rubinacci, E.E. Muller, C. Netti, Hexarelin, a growth hormone – releasing peptide, counteracts bone loss in gonadectomized male rats Growth Hormone & IGF Research. ,vol. 9, pp. 219- 227 ,(1999) , 10.1054/GHIR.1999.0105
Andrew D Howard, Scott D Feighner, Doris F Cully, Joseph P Arena, Paul A Liberator, Charles I Rosenblum, Michel Hamelin, Donna L Hreniuk, Oksana C Palyha, Jennifer Anderson, Philip S Paress, Carmen Diaz, Michael Chou, Ken K Liu, Karen Kulju McKee, Sheng-Shung Pong, Lee-Yuh Chaung, Alex Elbrecht, Mike Dashkevicz, Robert Heavens, Mike Rigby, Dalip JS Sirinathsinghji, Dennis C Dean, David G Melillo, Arthur A Patchett, Ravi Nargund, Patrick R Griffin, Julie A DeMartino, Sunil K Gupta, James M Schaeffer, Roy G Smith, Lex HT Van der Ploeg, None, A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release Science. ,vol. 273, pp. 974- 977 ,(1996) , 10.1126/SCIENCE.273.5277.974
Z. Laron, J. Frenkel, R. Deghenghl, S. Anin, B. Klinger, A. Siibergeld, Intranasal administration of the GHRP hexarelin accelerates growth in short children Clinical Endocrinology. ,vol. 43, pp. 631- 635 ,(1995) , 10.1111/J.1365-2265.1995.TB02929.X
C.Y. BOWERS, A.O. SARTOR, G.A. REYNOLDS, T.M. BADGER, On the Actions of the Growth Hormone-Releasing Hexapeptide, GHRP Endocrinology. ,vol. 128, pp. 2027- 2035 ,(1991) , 10.1210/ENDO-128-4-2027
David S. Weigle, R. Scott Frayo, Patricia A. Breen, Marina K. Ma, E. Patchen Dellinger, Jonathan Q. Purnell, David E. Cummings, Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery The New England Journal of Medicine. ,vol. 346, pp. 1623- 1630 ,(2002) , 10.1056/NEJMOA012908
Romano Deghenghi, Marco M. Cananzi, Antonio Torsello, Claudia Battisti, Eugenio E. Muller, Vittorio Locatelli, GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats Life Sciences. ,vol. 54, pp. 1321- 1328 ,(1994) , 10.1016/0024-3205(94)00510-9