Associations between TLR polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis.

摘要: OBJECTIVES The aim of this study was to determine whether the polymorphisms Toll-like receptor (TLR) confer susceptibility systemic lupus erythematosus (SLE). METHODS authors conducted a systematic review and meta-analysis reports on associations between TLR SLE susceptibility. RESULTS A total 8 studies (11 separate comparisons) were included in meta-analysis, which European Asian populations. Metaanalysis showed an association 2 allele rs3853839 (TLR7) subjects (OR 1.246; 95% CI 1.160, 1.388; p=2×10-9). No rs352139 (TLR9) have been performed Europeans. found alleles rs5743836 polymorphism all overall or Europeans, but one significant Asians 4.243; 1.487, 12.10; p=0.007). Furthermore, no rs5744168 (TLR5) Europeans rs187084 (TLR8) rs352140 Asians. CONCLUSIONS This suggests that TLR7 TLR9 are associated with development Further required contribute other ethnic groups.