Reprint of: B cell elimination in systemic lupus erythematosus

摘要: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution, potentially life-threatening considerable morbidity. The elimination of pathogenic B cells has emerged as rational therapeutic option. Many open label studies have reported encouraging results in which clinical and serological remission invariably been described, often enabling the reduction steroid immunosuppressive treatment. However, from randomized controlled disappointing several questions remain to be answered. In this review we will focus on cell direct depletion treatment patients systemic erythematosus.