Chapter 20. Complement Inhibitors

摘要: Publisher Summary It is generally accepted that the treatment of certain diseases may be effected through control complement consumption by interrupting generation or action cellular stimuli attending inflammatory processes. Such include chemoattractants for polymorphonuclear leukocytes, inducements noncytotoxic enzyme secretion, histamine releasing agents, and permeability factors. Three fenamic acids, flufenamic, mefanamic, niflumic, block classical pathway activity. Flufenamic acid was most active this group, showing significant inhibition at 0.05 mM with human complement. Aromatic amino acids represent another class compounds alter activity more than a single reaction step. possessing phenolic hydroxyl group were shown to especially in inhibiting C4 sites (IIc). Certain peptides have been interfere function. Leupeptin (acetyl-leucyl-leucyl–arginal), protease inhibitor derived from actinomycete fermentation, an effective inhibitor. In vitro (50%) 0.5 mM. Polynucleotides, polyanionic substances, phenols, amines, other groups also come under discussion on inhibitors. The inorganics shows zinc cation reported reversibly inhibit whole 0.025 0.50 utilization every component except C5 C9 inhibited (12%-55%) 0.025-0.50