Chemical and structural investigation of lipid nanoparticles: drug–lipid interaction and molecular distribution
作者： Suranan Anantachaisilp , Siwaporn Meejoo Smith , Alongkot Treetong , Sirapat Pratontep , Satit Puttipipatkhachorn
DOI: 10.1088/0957-4484/21/12/125102
关键词: Analytical chemistry 、 Crystallinity 、 Dynamic light scattering 、 Chemical engineering 、 Cetyl palmitate 、 Membrane fluidity 、 Drug delivery 、 Proton NMR 、 Lipid bilayer phase behavior 、 Chemistry 、 Nanoparticle 、 Mechanical engineering 、 Electrical and Electronic Engineering 、 General Materials Science 、 Mechanics of Materials 、 Bioengineering 、 General chemistry
摘要: Lipid nanoparticles are a promising alternative to existing carriers in chemical or drug delivery systems. A key challenge is determine how chemicals incorporated and distributed inside nanoparticles, which assists controlling retention release characteristics. This study reports the structural investigation of ?-oryzanol loading model lipid nanoparticle system composed cetyl palmitate as solid Miglyol 812? liquid lipid. The were prepared by high pressure homogenization at varying content, comparison with free size measured photon correlation spectroscopy, was found decrease increased content from 200 160?nm. High-resolution proton nuclear magnetic resonance (1H-NMR) measurements medium chain triglyceride has confirmed successful incorporation nanoparticles. Differential scanning calorimetric powder x-ray diffraction provide complementary results 1H-NMR, whereby crystallinity diminishes an increase content. For distribution 1H-NMR revealed that shifts loaded systems rather higher field than those systems, suggesting In addition, phase-separated structure observed atomic force microscopy for 0% lipid, but not 5 10% Raman spectroscopic mapping further preferential part Simple models representing lipids (solid liquid) proposed.
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