Endothelial progenitor cells in neovascularization of infarcted myocardium.

摘要: Historically, revascularization of ischemic tissue was believed to occur through the migration and proliferation endothelial cells in nearby tissues; however, evidence accumulated recent years indicates that a subpopulation adult, peripheral-blood cells, collectively referred as progenitor (EPCs), can differentiate into mature cells. After insult, EPCs are home sites neovascularization, where they contribute vascular regeneration by forming structural component capillaries secreting angiogenic factors; new also cardiomyocytes smooth-muscle These insights molecular cellular processes formation suggest cardiac function may be preserved after myocardial infarction transplanting heart tissue, thereby enhancing recovery. This therapeutic strategy has been effective animal models disorders, results from randomized clinical trials cell-based strategies safe feasible for treatment humans have provided early efficacy. However, scarcity peripheral blood several disease states reduce EPC number and/or prompted development overcome these limitations, such administration genetically modified overexpress growth factors. To optimize outcomes, researchers must continue refine methods purification, expansion, administration, develop techniques intrinsic phenotypic deficiencies EPCs.