Long-Term Dosing of Intrathecal Baclofen in the Treatment of Spasticity After Acquired Brain Injury.

摘要: Abstract Background Intrathecal baclofen (ITB) often is used to treat severe spasticity of cerebral origin. Although literature exists regarding the efficacy ITB, there has been minimal investigation related dosing in adult-acquired brain injury population, particularly at long-term duration. Objective To investigate ITB adult patients with origin due traumatic (TBI), stroke, and hypoxic-ischemic encephalopathy (HIE). Design Retrospective cohort study. Setting An academic outpatient rehabilitation clinic. Patients Forty-two secondary TBI, or HIE treated for greater than 3 years. Methods Medical records device manufacturer included were reviewed obtain demographic data, information, dates pump catheter placements, revisions. Main Outcome Measure Average daily doses mean change dose over 1, 2, Goal treatment (active function versus comfort/care/positioning) also was compared. Results Of 42 total patients, attributed either TBI (n = 19), stroke 11), 12). The (standard deviation) age 35.21 (10.17), 56.7 (13.1), 35.1 (12.4) years groups, respectively ( P .002). duration therapy 8.5 (5.0), 7.8 (3.4), 9.1 (4.6) .79). 596.9 (322.8) μg/d, 513.2 (405.7) 705.2 (271.7) μg/d .39). In subset more 5 years, percent between time chart review previously 7.3% (13.6), 12.7% (16), 24.7% (50.3), respectively. A complex pattern frequently those (36.4%) compared (9.7%) groups .04). Conclusion Despite use this cohort, continued require adjustments. There no significant difference a diagnosis HIE. stroke. Level Evidence III