Intrathecal baclofen associated with improvement of consciousness disorders in spasticity patients.
作者： Konstantinos Margetis , Stefanos I. Korfias , Stylianos Gatzonis , Nick Boutos , George Stranjalis
DOI: 10.1111/NER.12147
关键词: Spasticity 、 Minimally conscious state 、 Persistent vegetative state 、 Medicine 、 Traumatic brain injury 、 Anesthesia 、 Surgery 、 Coma 、 Consciousness Disorders 、 Level of consciousness 、 Baclofen
摘要: Objective Intrathecal baclofen (ITB) pump is a therapeutic option for persistent vegetative state and minimal conscious patients that have associated spasticity. We investigated whether this treatment modality can affect their level of consciousness. Method In prospective, open label, observational study, we implanted ITB pumps the spasticity in eight with disorders consciousness (vegetative minimally state) followed them Coma Recovery Scale-Revised, Eastern Cooperative Oncology Group (ECOG) performance scale, Modified Ashworth scale. Baclofen dose complications also were noted. Results The offending pathologies traumatic brain injury six, anoxia due to cardiac arrest one, acute obstructive hydrocephalus one. Two showed marked, improvement fulfilled criteria emergence from state. had prematurely removed because complications. The ECOG score was 4 all did not change during study. Conclusion ITB might be significant disorder two total six chronic treatment.
sci-hub.se 参考文章(49)
Hirofumi OYAMA, Akira KITO, Hideki MAKI, Kenichi HATTORI, Kuniaki TANAHASHI, Consciousness Recovery Induced by Intrathecal Baclofen Administration After Subarachnoid Hemorrhage Neurologia Medico-chirurgica. ,vol. 50, pp. 386- 390 ,(2010) , 10.2176/NMC.50.386
Takaomi Taira, Intrathecal administration of GABA agonists in the vegetative state. Progress in Brain Research. ,vol. 177, pp. 317- 328 ,(2009) , 10.1016/S0079-6123(09)17721-X
Christelle Peyron, Juliette Faraco, William Rogers, Beth Ripley, Sebastiaan Overeem, Yves Charnay, Sona Nevsimalova, Michael Aldrich, David Reynolds, Roger Albin, Robin Li, Marcel Hungs, Mario Pedrazzoli, Muralidhara Padigaru, Melanie Kucherlapati, Jun Fan, Richard Maki, Gert Jan Lammers, Constantin Bouras, Raju Kucherlapati, Seiji Nishino, Emmanuel Mignot, None, A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nature Medicine. ,vol. 6, pp. 991- 997 ,(2000) , 10.1038/79690
N.G. Bowery, Historical perspective and emergence of the GABAB receptor. Advances in pharmacology (San Diego). ,vol. 58, pp. 1- 18 ,(2010) , 10.1016/S1054-3589(10)58001-3
DOUGLAS T. ROSS, DAVID I. GRAHAM, J. HUME ADAMS, Selective loss of neurons from the thalamic reticular nucleus following severe human head injury. Journal of Neurotrauma. ,vol. 10, pp. 151- 165 ,(1993) , 10.1089/NEU.1993.10.151
Thomas C. Thannickal, Robert Y. Moore, Robert Nienhuis, Lalini Ramanathan, Seema Gulyani, Michael Aldrich, Marsha Cornford, Jerome M. Siegel, Reduced number of hypocretin neurons in human narcolepsy. Neuron. ,vol. 27, pp. 469- 474 ,(2000) , 10.1016/S0896-6273(00)00058-1
NG Bowery, K Parry, G Goodrich, I Ilinsky, K Kultas-Ilinsky, Distribution of GABAB binding sites in the thalamus and basal ganglia of the rhesus monkey (Macaca mulatta) Neuropharmacology. ,vol. 38, pp. 1675- 1682 ,(1999) , 10.1016/S0028-3908(99)00130-6
Francesca Pistoia, Marco Sarà, Simona Sacco, Antonio Carolei, None, Vegetative states and minimally conscious states revisited: a Russian doll approach. Brain Injury. ,vol. 27, pp. 1330- 1331 ,(2013) , 10.3109/02699052.2013.809554
Ronald T. Seel, Mark Sherer, John Whyte, Douglas I. Katz, Joseph T. Giacino, Amy M. Rosenbaum, Flora M. Hammond, Kathleen Kalmar, Theresa Louise-Bender Pape, Ross Zafonte, Rosette C. Biester, Darryl Kaelin, Jacob Kean, Nathan Zasler, Assessment Scales for Disorders of Consciousness: Evidence-Based Recommendations for Clinical Practice and Research Archives of Physical Medicine and Rehabilitation. ,vol. 91, pp. 1795- 1813 ,(2010) , 10.1016/J.APMR.2010.07.218
Xavier Hoarau, Edwige Richer, Patrick Dehail, Emmanuel Cuny, A 10-year follow-up study of patients with severe traumatic brain injury and dysautonomia treated with intrathecal baclofen therapy. Brain Injury. ,vol. 26, pp. 927- 940 ,(2012) , 10.3109/02699052.2012.661913