Clinical Aspects of Osteoporosis

摘要: Osteoporosis is the most frequent generalized bone disease, characterized by a uniform pathogenesis in form of pathologically negative balance and heterogeneous etiology, many respects still unexplained even today. It gains particular socio-medical importance due to its complications which can lead absence from work premature disablement. On basis our detailed account osteoporosis chapter 1980 edition Handbook Internal Medicine I intend following lecture report on selection research results are either new or meantime have been verified order throw light problems occure each time different at every time-dependent phase an illness — that also applies (Kuhlencordt Kruse 1980). In study we dated start back 1885 mentioned Pommer who defined anatomically, separating it physiological age-dependent atrophy skeleton changes constantly occuring throughout life, finally leads reduction formation as compared with resorption increasing age. Clinical this field cannot be spoken until few decades later, when fundamental studies Albright his team were published. et al. described 1940 1941 “postmenopausal osteoporosis” could already prove positive effect oestrogen therapy now once more midst attention after partly controversal discussion. Albright’s position seen book he wrote Reifen-stein 1948 “Parathyroid Glands Metabolic Bone Disease”, along 118 86 co-authors, 19 syndromes (Henneman 1970).