Instrumentation for Radionuclide Cardiology

摘要: Radioactive tracers have been employed for the evaluation of cardiac structure and function over 50 years. The discipline had its genesis in 1927 with innovative experiments Blumgart Weiss [1]. These investigators, utilizing principles radioactive tracer method devised by Hevesy [2], measured circulation man injecting a dose radium C-salt (radon) into an antecubital vein detecting arrival contralateral brachial artery Wilson cloud chamber. This technique was revived Prinzmetal associates [3] 1948 advent atomic age technology. Using Geiger-Muller counter artifical radionuclide 24Na, these investigators repeated determination time also recording temporal changes radioactivity heart lungs. angiocardiogram thus discovered. Many improvements instrumentation radiopharmaceuticals since introduced to facilitate central circulation. Cardiovascular nuclear medicine procedures today encompass myriad qualitative quantitative techniques including: (1) detection quantitation intracardiac shunts, (2) measurements regional myocardial blood flow, (3) visualization anatomic relationships major cardiovascular structures — such as chamber dilatation, ventricular or septal hypertrophy, pericardial effusion, aneu-rysm, (4) identification clot mass, (5) mechanical function, (6) identification, localization, sizing acute infarcts, (7) noninvasive assessment perfusion at rest during exercise pharmacologic stress, (8) severity valvular regurgitation, (9) metabolism.