Fluvastatin reduces endothelin secretion of cultured human umbilical vein endothelial cells.

作者: A. O. Mueck , H. Seeger , T. H. Lippert

DOI: 10.1007/S002280050683

关键词: Endothelin secretionUmbilical veinHydroxymethylglutaryl-CoA reductaseEndocrinologyBlood vesselBiologyReductaseEndothelin receptorFluvastatinInternal medicineEndothelial stem cell

摘要: Objective: Fluvastatin is an agent of a new lipid lowering drug class, the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, which seems to elicit direct effects on vasculature.

参考文章(4)
O Hernández-Perera, D Pérez-Sala, J Navarro-Antolín, R Sánchez-Pascuala, G Hernández, C Díaz, S Lamas, Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. Journal of Clinical Investigation. ,vol. 101, pp. 2711- 2719 ,(1998) , 10.1172/JCI1500
Hans Lennernäs, Gunnar Fager, Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences. Clinical Pharmacokinectics. ,vol. 32, pp. 403- 425 ,(1997) , 10.2165/00003088-199732050-00005
Carl J Vaughan, Michael B Murphy, Brendan M Buckley, Statins do more than just lower cholesterol The Lancet. ,vol. 348, pp. 1079- 1082 ,(1996) , 10.1016/S0140-6736(96)05190-2