Predictive value of cystic fibrosis transmembrane conductance regulator (CFTR) in the diagnosis of gastric cancer.
作者： Haiyan Liu , Wenyong Wu , Yang Liu , Changle Zhang , Zheng Zhou
关键词: Poor prognosis 、 Cancer 、 Endocrinology 、 Internal medicine 、 Gastroenterology 、 Serum samples 、 Predictive value 、 Receiver operating characteristic 、 Medicine 、 Carcinoembryonic antigen 、 Stage (cooking) 、 Cystic fibrosis transmembrane conductance regulator
摘要: Purpose: Gastric cancer is associated with poor prognosis. The high mortality rate of gastric mainly attributed to late detection, so diagnosis and treatment are crucial decreasing mortality. purpose this study was examine the predictive accuracy discriminative ability cystic fibrosis transmembrane conductance regulator (CFTR) in patients, addition classical tumor biomarkers carbohydrate antigen 199 (CA199) carcinoembryonic (CEA). Methods: performed on 78 serum samples from patients 88 healthy adults. Serum levels CFTR, CA199, CEA CHN were determined by enzyme-linked immunosorbent assay (ELISA) Results: Spearman’s coefficient analysis showed that, some cases, CFTR strongly correlated CA199 that increased age. Kruskal-Wallis testing indicated concentrations had statistically significant association stage. Logistic regression independently predicted cancer. Receiver operating characteristics (ROC) combinations yielded best ROC curve, an AUC 0.875. Conclusions: results indicate has a broad application prospects for detection GC.
cimonline.ca参考文章(25)
P Maisonneuve, M H Schöni, F Schöni-Affolter, A B Lowenfels, Cancer risk in patients with cystic fibrosis: the European data. CF/CSG Group. Journal of the Royal Society of Medicine. ,vol. 89, pp. 38- 43 ,(1996)
Wei-Jei Lee, I-Rue Lai, Hshu-Hshing Lin, Ming-Te Huang, Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence. Hepato-gastroenterology. ,vol. 49, pp. 1157- 1160 ,(2002)
Chunying Li, Anjaparavanda P. Naren, Analysis of CFTR Interactome in the Macromolecular Complexes Methods in Molecular Biology. ,vol. 741, pp. 255- 270 ,(2011) , 10.1007/978-1-61779-117-8_17
Xiaoming Liu, Qinshi Jiang, S. Gary Mansfield, M. Puttaraju, Yulong Zhang, Weihong Zhou, Jonathan A. Cohn, Mariano A. Garcia-Blanco, Lloyd G. Mitchell, John F. Engelhardt, Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans -splicing Nature Biotechnology. ,vol. 20, pp. 47- 52 ,(2002) , 10.1038/NBT0102-47
Hsiao Chang Chan, Ye Chun Ruan, Qiong He, Min Hui Chen, Hui Chen, Wen Ming Xu, Wen Ying Chen, Chen Xie, Xiao Hu Zhang, Zhen Zhou, The cystic fibrosis transmembrane conductance regulator in reproductive health and disease The Journal of Physiology. ,vol. 587, pp. 2187- 2195 ,(2009) , 10.1113/JPHYSIOL.2008.164970
Zheng Zhou, Jianan Ren, Haiyan Liu, Guosheng Gu, Jieshou Li, Serum proteomic analysis from bacteremic and leucopenic rabbits. Journal of Surgical Research. ,vol. 171, pp. 749- 754 ,(2011) , 10.1016/J.JSS.2010.04.056
Hakan Camlica, Derya Duranyildiz, Hilal Oguz, Ethem Nezih Oral, Vildan Yasasever, The Diagnostic Value of Macrophage Migration Inhibitory Factor (MIF) in Gastric Cancer Pathology & Oncology Research. ,vol. 14, pp. 79- 83 ,(2008) , 10.1007/S12253-008-9002-7
Heike Grassmé, Katrin Anne Becker, Yang Zhang, Erich Gulbins, CFTR-dependent susceptibility of the cystic fibrosis-host to Pseudomonas aeruginosa International Journal of Medical Microbiology. ,vol. 300, pp. 578- 583 ,(2010) , 10.1016/J.IJMM.2010.08.011
G. B. Pier, Role of the cystic fibrosis transmembrane conductance regulator in innate immunity to Pseudomonas aeruginosa infections Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 8822- 8828 ,(2000) , 10.1073/PNAS.97.16.8822
CD Sheldon, ME Hodson, LM Carpenter, AJ Swerdlow, A cohort study of cystic fibrosis and malignancy British Journal of Cancer. ,vol. 68, pp. 1025- 1028 ,(1993) , 10.1038/BJC.1993.474