Versatile effects of sildenafil: recent pharmacological applications.
作者： Subramaniam Uthayathas , Senthilkumar S Karuppagounder , Bessy M Thrash , Kodeeswaran Parameshwaran , Vishnu Suppiramaniam
DOI:
关键词: Glutamate receptor 、 Sildenafil 、 Pulmonary hypertension 、 Nitric oxide 、 cGMP-dependent protein kinase 、 Central nervous system 、 Neuroprotection 、 Pharmacology 、 Medicine 、 Erectile dysfunction
摘要: Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor and predominantly used in the treatment of erectile dysfunction. While maintaining an excellent safety tolerability profile management dysfunction, sildenafil also provides prolonged benefit various other diseases. has been shown to have potential therapeutic efficacy for disorders related central nervous system pulmonary system. In system, it exerts its neuroprotective effects multiple sclerosis significant memory enhancing action. significantly enhances neurogenesis. Several lines evidence indicate that targeting PDE5 with offers novel strategies age-related impairment. Guanylate cyclase/cGMP/protein kinase G pathway or glutamate/nitric oxide/cGMP appears mediate effects. Some positive cognitive features therapy are likely attributable mechanisms reviewed here. reduce hypertension alleviate pain animals humans. The present review primarily focuses on pharmacological regard influence
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