Sibling Recurrence Risk in Autoimmune Thyroid Disease
作者： R. Villanueva , D.A. Greenberg , T.F. Davies , Y. Tomer
DOI: 10.1089/105072503768499653
关键词: Pediatrics 、 Thyroid 、 Thyroiditis 、 Sibling 、 Relative risk 、 Internal medicine 、 Proband 、 National Health and Nutrition Examination Survey 、 Prevalence 、 Disease 、 Endocrinology 、 Medicine 、 Endocrinology, Diabetes and Metabolism
摘要: There is abundant evidence for a genetic influence on the development of autoimmune thyroid diseases (AITD). One measure magnitude contribution to disease sibling risk ratio (λs). Recent accurate prevalence data hypothyroidism and hyperthyroidism in United States reported from National Health Nutrition Examination Survey III (NHANES III) study have now allowed us compute recurrence AITD. Patients were recruited our endocrine clinic basis having The inclusion patients this was unambiguously single ascertainment. We studied 155 (131 with Graves' [GD] 24 Hashimoto's thyroiditis [HT]) who had reliable information presence or absence AITD siblings. Nine probands siblings GD 13 HT. Using rates NHANES clinical hypothyroidism, calculated λs 16.9 AITD, 11.6 for...
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