Lung transplantation: a treatment option in end-stage lung disease.

摘要: For patients with terminal lung conditions such chronic obstructive disease (COPD), transplantation (LuTx) offers treatment to improve quality of life and additionally, in those certain other diseases—e.g., cystic fibrosis (CF), idiopathic pulmonary (IPF), arterial hypertension (PAH)—to prolong (1, 2, e1). It is used at the point when, despite by all available conservative methods, patient’s will be clearly impaired or shortened if does not take place (3, 4, e2). At present, there are four main surgical options when performing a (5, e3, e4). These are: Unilateral (single lung) (SLuTx) Bilateral (double (DLuTx) Combined heart–lung (HLuTx) Transplantation individual lobes from living donors. The last these practiced only few centers world, present burdened weight, non-negligible risks for two healthy donors, but also an agglomeration associated ethical difficulties, this reason it discussed further article (e5). Analysis data relevant registries show that transplantations have been continually on rise over past 5 years, reduction numbers willing donors. Worldwide, increase estimated 30% (International Society Heart Lung Transplantation, ISHLT), while Germany figure 19% (German Foundation Organ DSO [Deutsche Stiftung Organtransplantation]). According ISHLT, 3519 were carried out worldwide 2010, 298 them (6, 7, e6). 2012, recorded 357 organ (7). against background positive development has written give up-to-date overview topic transplantation, answer questions key components therapy: recipient selection, contraindications, waiting lists, allocation procedures, procedure, postoperative immune suppression, aftercare, early late complications, rehabilitation, recent long-term results (eFigure). eFigure Interaction between current clinical practice transplantation.