Synthesis and in vitro inhibitory effect of L-glycosyl-branched curdlan sulfates on AIDS virus infection

摘要: Such natural and nonnatural sugars as D- L-glucoses L-mannose were reacted with curdlan to form branched curdlans, respectively. These structures analyzed by means of 13 C NMR spectroscopy methylation analysis. The branche curdlans sulfated piperidine-N-sulfonic acid in DMSO give sulfates. It was revealed at these sulfates had high anti-AIDS virus activities the EC 50 range 0.3-1.2 μg/mL vitro using MT-4 cells exhibited low cytotoxicities well anticoagulant activities. Furthermore, fon-glycosyl-branched states, retention times rat vivo calculating from their a few hours