Neo-striatal rCBF correlates of psychomotor slowing in patients with major depression
作者： Ian Hickie , Philip Ward , Elizabeth Scott , Walter Haindl , Brenda Walker
DOI: 10.1016/S0925-4927(99)00038-4
关键词: Depression (differential diagnoses) 、 In patient 、 Single photon emission computerised tomography 、 Psychomotor learning 、 Neuroscience 、 Internal medicine 、 Psychomotor disorder 、 Psychology 、 Hexamethylpropylene amine oxime 、 Cerebral blood flow 、 Hemodynamics 、 Cardiology
摘要: Abstract Psychomotor slowing is a fundamental clinical feature of severe depression and thought to reflect dysfunction within prefrontal-subcortical circuits. This study utilised split-dose single photon emission computerised tomography (SPECT) scanning technique in association with two-stage test psychomotor speed. Twenty-five patients primary depressive disorders were injected technetium-99m hexamethylpropylene amine oxime ( 99m Tc-HMPAO) whilst performing each component task. The first stage, ‘simple reaction time' (RT) the second ‘choice (CRT), followed by 30-min SPECT scans. Regions interest (ROIs) corresponding left right neo-striatum (caudate-putamen) drawn, regional cerebral blood flow (rCBF) values calculated. Importantly, change rCBF measure was inversely correlated RT r =−0.48, P
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