Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirus.
作者： E. Gönczöl , L. Váczi , Istvan Boldogh
DOI:
关键词: Transformation (genetics) 、 Fibroblast 、 Cytoplasm 、 Antigen 、 Embryonic stem cell 、 Hamster 、 Molecular biology 、 Cell culture 、 Virology 、 Human cytomegalovirus 、 Chemistry
摘要: Infection of hamster embryonic fibroblast (HEF) cells with UV-irradiated human CMV resulted in appearance transformed clones. The established cell line (87-TRH-5) when inoculated subcutaneously induced tumour newborn hamsters. 87-TRH-5 and the lines (87-TRH-5-Tsc1, 87-TRH-5-Tsc2, 87TRH-5-Tsc3) developed from tumour, proved to bear CMV-spcific cytoplasmic surface antigens. Demonstration infectious or MCV-specific nuclear antigen 87-THR-5-cells has failed.
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