Molecular Studies on the Cytomegaloviruses of Mice and Men

摘要: The cytomegaloviruses (CMV) are among the largest animal viruses, and on basis of morphological biochemical characteristics, they have been classified in herpesvirus group. hallmark this group viruses is their ability to cause persistent latent infections. In last 20 years, human CMV (HCMV), particular, has gained recognition as its association with a broad spectrum diseases potential oncogenic capacity appreciated (for review see 1–4). Congenital infection HCMV represents most frequent viral newborns involves approximately 1% all live births. Although immunocompetent children adults usually asymptomatic, it can result pneumonia, hepatitis, heterophile-negative mononucleosis, chorioretinitis or encephalitis. also serious problem for individuals who immunocompromised either therapeutically disease. these individuals, primary reactivation virus often leads interstitial pneumonia death.