A Concerted Appeal for International Cooperation in Preclinical Stroke Research

摘要: > Despite dramatic advances in the molecular pathogenesis of disease, translation basic biomedical research into safe and effective clinical applications remains a slow, expensive, failure-prone endeavor. > Francis S. Collins1 The global burden stroke on patients, their relatives, health systems, economies that support them is tremendous. In an unprecedented move, World Health Organization (WHO) United Nations have responded to this challenge by declaring fight against top priority drive prevent control noncommunicable diseases.2 Indeed, great progress has been made our understanding pathophysiology. This led development thrombolysis, highly efficient therapy for subset patients with acute ischemic stroke. We came realize responses brain tissue substrate deprivation are complex, not only neurons need be considered but also glial vascular cells, as well local or blood-derived cells immune system.3–5 now know ischemia triggers multitude endogenous protective mechanisms which help contain lesion evolution protect from further damage.6 The tremendous capacity overcome functional deficits, we begin understand how plasticity works, actually finding evidence repair.7 beginning appreciate interaction between other organ such system,8 cardiovascular system, systemic metabolism, multidirectional signaling impact outcome stroke.9 Taken together, during past few decades suggested numerous targets therapeutic intervention restore perfusion, block damage, induce protection, intercept deleterious …