The Dark Side of the Force - Constraints and Complications of Cell Therapies for Stroke.

摘要: Cell therapies are increasingly recognized as a promising option to augment the limited therapeutic arsenal available fight ischemic stroke. During last two decades, cumulating preclinical evidence has indicated substantial efficacy for most cell treatment paradigms and first clinical trials currently underway assess safety feasibility in patients. However, strong still unmet demand novel stroke options exciting findings reported from experimental studies may have drawn our attention away potential side effects related ways by which they commonly applied. This review summarizes common less frequent adverse events that been discovered investigations assessing Such range immunological neoplastic complications over seizures clotting cell-induced embolism. It also describes of clinically applicable administration procedures, detrimental interactions between cells, pathophysiological environment placed into, well problems manufacturing. Virtually each intervention comes at certain risk complications. Side do therefore not generally compromise value treatments stroke, but underestimating such might severely limit protocols under development. On other hand, better understanding will provide opportunities further improve existing strategies help define those circumstances, an optimal effect can be realized. Hence, eventually discusses recommendations allowing us prevent or least balance order ensure maximum benefit minimum