Association between two genetic variants in miRNA and primary liver cancer risk in the Chinese population.

摘要: MicroRNAs (miRNAs) play an important role in the growth and development of human beings. Single nucleotide polymorphisms (SNPs) within miRNA could change their production or affinity with target genes, thus leading to malignant diseases. This case-control study conducted Western China aimed explore relationship between miR-146a (rs2910164 G>C) miR-499 (rs3746444 T>C) primary liver cancers Chinese population. 186 cancer cases 483 healthy controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism. No significant differences observed distributions two SNPs susceptibility diverse clinicopathologic features. However, we found that patients genotype CG SNP tended have earlier onset better function than CC (average age: 49.9 vs. 54.9, p=0.038; average Child-Pugh grade: 5.55 6.15, p=0.021), further analysis showed who had at least one G allele diagnosed age 49.6 p=0.022) grade:5.60 p=0.026). Our data suggested lack association risk, though, interestingly, may influence grade.