Biodegradable comb polyesters: Part 1 synthesis, characterization and structural analysis of poly(lactide) and poly(lactide-coglycolide) grafted onto water-soluble poly(vinyl alcohol) as backbone
作者： Armin Breitenbach , Thomas Kissel
DOI: 10.1016/S0032-3861(97)10077-5
关键词: Polymerization 、 Materials science 、 Drug carrier 、 Biodegradable polymer 、 Lactide 、 Polymer chemistry 、 Polymer 、 Polyester 、 Static light scattering 、 Vinyl alcohol
摘要: Abstract To overcome discontinuous or polyphasic drug release rates of parenteral delivery systems (PDSs) for peptides and proteins, typical linear polyesters, novel biodegradable brush-like poly(lactide) poly(lactide-co-glycolide) (PLG) grafted onto water-soluble poly(vinyl alcohol) (PVA) as backbone were investigated. These polymers synthesized by ring-opening melt polymerization using stannous octoate catalyst. The branched PVA-PLGs characterized 1D- 2D-n.m.r. spectroscopy other methods, such i.r., g.p.c., d.s.c. static light scattering. incorporation the comb structure was demonstrated 1H- 13C - n.m.r. spectra, well scattering studies. physico-chemical properties, molecular composition architecture, weight, degree crystallinity, melting point glass transition point, could be systematically adjusted to requirements delivery. Therefore, this new class has considerable potential a PDS.
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