Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice.
作者： Chenglai Xia , Zhihong He , Shaofen Liang , Ruihong Chen , Weikang Xu
DOI: 10.1016/J.EJPHAR.2019.01.045
关键词: Nelfinavir 、 Chemistry 、 Cancer research 、 Lactate dehydrogenase 、 SIRT3 、 Cytotoxicity 、 Metformin 、 Blot 、 Nude mouse 、 Autophagy
摘要: The molecular mechanisms underlying the antineoplastic properties of metformin combined with nelfinavir remain elusive. To explore this question, transmission electron microscopy …
sci-hub.se 参考文章(41)
Lewis L. Lanier, A renaissance for the tumor immunosurveillance hypothesis Nature Medicine. ,vol. 7, pp. 1178- 1180 ,(2001) , 10.1038/NM1101-1178
Cui Zhang, Yingnan Jiang, Jin Zhang, Jian Huang, Jinhui Wang, 8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells International Journal of Molecular Sciences. ,vol. 16, pp. 14979- 14996 ,(2015) , 10.3390/IJMS160714979
Rui Huang, Wei Liu, Identifying an essential role of nuclear LC3 for autophagy Autophagy. ,vol. 11, pp. 852- 853 ,(2015) , 10.1080/15548627.2015.1038016
Päivi Ylä‐Anttila, Helena Vihinen, Eija Jokitalo, Eeva‐Liisa Eskelinen, Monitoring autophagy by electron microscopy in Mammalian cells. Methods in Enzymology. ,vol. 452, pp. 143- 164 ,(2009) , 10.1016/S0076-6879(08)03610-0
Sebastian Wesselborg, Björn Stork, Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cellular and Molecular Life Sciences. ,vol. 72, pp. 4721- 4757 ,(2015) , 10.1007/S00018-015-2034-8
T. Orfanelli, J.M. Jeong, G. Doulaveris, K. Holcomb, S.S. Witkin, Involvement of autophagy in cervical, endometrial and ovarian cancer. International Journal of Cancer. ,vol. 135, pp. 519- 528 ,(2014) , 10.1002/IJC.28524
Fausto Petrelli, Agostina De Stefani, Francesco Raspagliesi, Domenica Lorusso, Sandro Barni, Radiotherapy with concurrent cisplatin-based doublet or weekly cisplatin for cervical cancer: A systematic review and meta-analysis Gynecologic Oncology. ,vol. 134, pp. 166- 171 ,(2014) , 10.1016/J.YGYNO.2014.04.049
Ai Yu YAO, Hai Yang TANG, Yun WANG, Mei Fu FENG, Rou Li ZHOU, Inhibition of the activating signals in NK92 cells by recombinant GST-sHLA-G1α chain Cell Research. ,vol. 14, pp. 155- 160 ,(2004) , 10.1038/SJ.CR.7290215
Robin Mathew, Eileen White, Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night Current Opinion in Genetics & Development. ,vol. 21, pp. 113- 119 ,(2011) , 10.1016/J.GDE.2010.12.008
V. Groh, R. Rhinehart, H. Secrist, S. Bauer, K. H. Grabstein, T. Spies, Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 6879- 6884 ,(1999) , 10.1073/PNAS.96.12.6879