Hypoxia-induced NAD+ interventions promote tumor survival and metastasis by regulating mitochondrial dynamics.
作者： Xiaoyu Yan , Xianzhi Qu , Rui Tian , Long Xu , Xue Jin
DOI: 10.1016/J.LFS.2020.118171
关键词:
摘要: Hypoxia, an important feature of the tumor microenvironment, is responsible for chemo-resistance and metastasis malignant solid tumors. Recent studies indicated that mitochondria undergo morphological transitions as adaptive response to maintain self-stability connectivity under hypoxic conditions. NAD+ may not only provide reducing equivalents biosynthetic reactions in determining energy production, but also functions a signaling molecule mitochondrial dynamics regulation. In this review, we describe upregulated KDAC deacetylase expression cytoplasm cells results from sensing changes control distribution, which survival hypoxia.
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