A system model for cell death using Fuzzy and SPICE

摘要: A family of cystein-dependent aspartate-directed proteases, called caspases, is responsible for the proteolytic cleavage cellular proteins leading to characteristic apoptotic features, e.g. caspase-activated DNase resulting in inter nucleosomal DNA fragmentation. Currently, two pathways activating caspases have been studied detail. One starts with ligation a death ligand its transmembrane receptor, followed by recruitment and activation death-inducing signaling complex. The second pathway involves participation mitochondria, which release caspase-activating into cytosol, thereby forming apoptosome where will bind become activated. In addition, other are emerging: endoplasmic reticulum stress-induced apoptosis caspase-independent apoptosis. model cell has implemented using Fuzzy CMOS logic SPICE taking three input signals: Tumor necrosis factor-α (TNF), Epidermal growth factor (EGF) Insulin.