Facilitatory effect of phorbol ester on 2-deoxyglucose uptake in rat hippocampal slices
作者： Shigenobu Shibata , Ayako Nakashio , Showa Ueki , Shigenori Watanabe
DOI: 10.1016/0922-4106(93)90105-I
关键词: Premovement neuronal activity 、 K252a 、 Carbachol 、 Chemistry 、 Staurosporine 、 Endocrinology 、 Long-term potentiation 、 Internal medicine 、 Protein kinase C 、 Deoxyglucose 、 Glutamate receptor 、 Pharmacology
摘要: Abstract It is well known that synaptic potentiation in the hippocampus can be produced by phorbol ester, a protein kinase C activator. The 2-deoxyglucose uptake an index of regional glucose utilization which predominantly reflects activity axonal terminal neuronal pathways. In present experiment, therefore, we examined whether application ester produces facilitatory effect on rat vitro. phorbol-12,13-dibutyrate (PdBU) elevation uptake, while pretreatment with PdBU for 60 min eliminated pdBU-induced elevation. Pretreatment inhibitors, K252a (0.1 and 1 μM) or staurosporine μM), was found to block significantly PdBU-induced uptake. addition, glutamate, quisqualate carbachol reduced PdBU. demonstrated caused linked turn activity, suggesting positive relationship between activation energy consumption.
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