Activation of a K-252b-Sensitive Protein Kinase is Necessary for a Post-Synaptic Phase of Long-Term Potentiation in Area CA1 of Rat Hippocampus.
作者： K. G. Reymann , S. N. Davies , H. Matthies , H. Kase , G. L. Collingridge
DOI: 10.1111/J.1460-9568.1990.TB00439.X
关键词:
摘要: K-252b, a potent inhibitor of protein kinases blocked late phase long-term potentiation (LTP) in area CA1 rat hippocampal slices, resulting decremental LTP. It also prevented the slowly developing increase sensitivity neurons to iontophoretically administered alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) which was seen control slices that exhibit nondecremental However, K-252b applied 60 - 180 min after induction LTP had no effect on potentiated synaptic and AMPA-induced responses. A K-252b-sensitive kinase may therefore be involved postsynaptic component
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