Biochemical Correlates of Long-Term Potentiation in Hippocampal Synapses

摘要: Publisher Summary This chapter discusses the biochemical events that are currently known or hypothesized to participate in Long-term potentiation (LTP) induction/maintenance. The current evidence strongly suggests postsynaptic Ca 2+, both entered from outside of cells and released intracellular stores, is initial key substance for induction LTP. A rise [Ca 2+ ] i triggers a variety enzymatic reactions initiates enhancement synaptic transmission. first step may be achieved by direct/ indirect phosphorylations protein molecules receptors/ion channels. result an increase receptor sensitivity. An immediate number available receptors modifications spine morphology another candidate. Such accomplished cytoskeleton rearrangements changes extracellular environments. change structure also cause spine-neck conductance. Although it unknown what extent affects cellular chemistry, probably directly/indirectly stimulates cascades which exert effects more slowly. delayed metabotropic sensitivity occur. New synthesis involved late periods LTP replacing turnovered and/or supplying new materials.