Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis.
作者： Lei Shi , Michelle M Adams , M Constance Linville , Isabel G Newton , M Elizabeth Forbes
DOI: 10.1016/J.EXPNEUROL.2007.03.026
关键词:
摘要: Caloric restriction (CR) extends life span and ameliorates the aging-related decline in hippocampal-dependent cognitive function. In present study, we compared subunit levels of NMDA AMPA types glutamate receptor quantified total synapses multiple spine bouton (MSB) hippocampal CA1 from young (10 months), middle-aged (18 old (29 months) Fischer 344×Brown Norway rats that were ad libitum (AL) fed or caloric restricted 4 months age. Each these parameters has been reported to be a potential contributor Western blot analysis revealed subunits AL animals decrease between middle age are at Interestingly, CR have significantly lower than those maintained across span. contrast, stereological quantification indicated MSB stable both rats. These results indicate significant losses consistent with altered synaptic eliminates by inducing levels.
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sci-hub.se 参考文章(84)
Maria Fischer, Stefanie Kaech, Uta Wagner, Heike Brinkhaus, Andrew Matus, Glutamate receptors regulate actin-based plasticity in dendritic spines. Nature Neuroscience. ,vol. 3, pp. 887- 894 ,(2000) , 10.1038/78791
C. Lüscher, R. A. Nicoll, R. C. Malenka, D. Muller, Synaptic plasticity and dynamic modulation of the postsynaptic membrane Nature Neuroscience. ,vol. 3, pp. 545- 550 ,(2000) , 10.1038/75714
Satoru Otani, Yehezkel Ben-Ari, Biochemical Correlates of Long-Term Potentiation in Hippocampal Synapses International Review of Neurobiology. ,vol. 35, pp. 1- 41 ,(1993) , 10.1016/S0074-7742(08)60567-X
Geoffrey C. Tombaugh, Wayne B. Rowe, Ana R. Chow, Timothy H. Michael, Gregory M. Rose, Theta-Frequency Synaptic Potentiation in CA1In VitroDistinguishes Cognitively Impaired from Unimpaired Aged Fischer 344 Rats The Journal of Neuroscience. ,vol. 22, pp. 9932- 9940 ,(2002) , 10.1523/JNEUROSCI.22-22-09932.2002
D. Muller, N. Toni, P.-A. Buchs, I. Nikonenko, C. R. Bron, LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite Nature. ,vol. 402, pp. 421- 425 ,(1999) , 10.1038/46574
W Fischer, A Bjorklund, K Chen, FH Gage, NGF improves spatial memory in aged rodents as a function of age The Journal of Neuroscience. ,vol. 11, pp. 1889- 1906 ,(1991) , 10.1523/JNEUROSCI.11-07-01889.1991
Thressa D. Smith, Michelle M. Adams, Michela Gallagher, John H. Morrison, Peter R. Rapp, Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged Rats The Journal of Neuroscience. ,vol. 20, pp. 6587- 6593 ,(2000) , 10.1523/JNEUROSCI.20-17-06587.2000
R. J. McCarter, J. R. McGee, Transient reduction of metabolic rate by food restriction American Journal of Physiology-endocrinology and Metabolism. ,vol. 257, ,(1989) , 10.1152/AJPENDO.1989.257.2.E175
Theresa A. Jones, Catherine J. Chu, Lucinda A. Grande, Aurora D. Gregory, Motor Skills Training Enhances Lesion-Induced Structural Plasticity in the Motor Cortex of Adult Rats The Journal of Neuroscience. ,vol. 19, pp. 10153- 10163 ,(1999) , 10.1523/JNEUROSCI.19-22-10153.1999
B. P. Yu, E. J. Masoro, C. A. McMahan, Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics Journal of Gerontology. ,vol. 40, pp. 657- 670 ,(1985) , 10.1093/GERONJ/40.6.657