The role of N-methyl-d-aspartate receptors in the generation of short-term potentiation in the rat hippocampus
作者： R. Anwyl , D. Mulkeen , M.J. Rowan
DOI: 10.1016/0006-8993(89)91716-2
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摘要: The effects of stimulus intensity and the N-methyl-D-aspartate (NMDA) antagonist 2-amino-5-phosphonovalerate (AP5) were studied on induction short-term potentiation (STP) long-term (LTP) in CA1 rat hippocampal slice. A tetanus very weak stimuli produced STP, also LTP providing applied form a series high frequency trains rather than one continuous train. Increasing to just threshold for spike initiation larger amplitude STP LTP. AP5 strongly inhibited as well by trains, indicating large component this was generated activation NMDA receptors. further residual AP5, which associated with decrease paired pulse facilitation, is probably presynaptic increase probability transmitter release.
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