Characterization of the integration time for the stabilization of long- term potentiation in area CA1 of the hippocampus

摘要: In area CA1 of the hippocampus, synaptic activation NMDA receptors during postsynaptic depolarization can generate either a decremental potentiation termed short-term (STP) or stable, long-term (LTP). Examining relationship between these two forms enhancement should provide information about intracellular processes responsible for stabilization LTP. Using hippocampal slice preparation, initial experiments confirmed that STP be generated by weak tetanus pairing single EPSP with depolarization. Following generation submaximal LTP, application weak, STP-inducing resulted in (not LTP), suggesting stabilizing LTP must activated induction and cannot accessed at later times. To determine interval over which integrated result stable (the “integration time” fixed number afferent stimuli were given varying intervals (5–60 sec) extracellular whole-cell recording, was rarely (11% experiments) elicited 1 min frequently (76% 10 sec intervals. These results indicate following depolarization, decay significantly within approximately min, although this value may depend on level requisite processes.