The role of protein kinase C in long-term potentiation: a testable model
作者： David J. Linden , Aryeh Routtenberg
DOI: 10.1016/0165-0173(89)90004-0
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摘要: With the use of appropriate reagents, LTP may be divided into at least two stages, induction and maintenance. Induction is dependent upon activation NMDA receptor, consequent influx calcium postsynaptic cell. Both correlational evidence (measures PKC activity, protein F1 phosphorylation, PI turnover) interventive (application inhibitors activators) indicate that necessary for maintenance response. An important regulatory pathway liberation c-FAs from membrane phospholipids by PLA2. In LTP, this stabilize in an activated state, thus contribute to potentiated could result presynaptic alteration (increased neurotransmitter release), (increases receptor number or sensitivity, alterations morphology), synapse addition, any these processes combination. If mediated alteration, as has been indicated measurement glutamate release, then one must posit a signal travels activate PKC. Alternatively, if contained within dendritic spine would suffice PKC-mediated processes. We suggest contributions determined differential distribution subtypes substrates among hippocampal synaptic zones.
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