Anoxia reveals a vulnerable period in the development of long-term potentiation.
作者： Amy Arai , John Larson , Gary Lynch
DOI: 10.1016/0006-8993(90)90184-D
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摘要: Abstract Transient anoxia occurring 1–2 min after high-frequency stimulation selectively prevented the stable expression of long-term potentiation (LTP). Anoxia this brief vulnerable period did not reverse LTP. Experiments on duration necessary to block LTP indicated that simply reducing synaptic transmission was insufficient but membrane depolarization required. The effects were blocked by antagonists A1 adenosine receptors.It is concluded develops in about one minute and chemistries operating are easily disrupted an event triggered receptors.
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