Induction and Stabilization of Long-Term Potentiation

摘要: A significant body of evidence implicates long-term potentiation (LTP) in the encoding certain types memory. LTP is triggered by very brief periods high frequency synaptic activity, can persist unchanged for weeks (Staubli and Lynch 1987), selective to connections stimulated (Lynch et. al. 1977; Andersen 1977). These are all properties expected a memory substrate. Further correlational found close correspondence between optimal stimulation parameters inducing patterns physiological activity occurring hippocampus during learning. Thus, experiments using (30 msec) bursts have shown that spacing 100–200 msec (Larson et 1986; Larson 1986), which period theta EEG rhythm animals exploring their environments (see Vanderwolf 1969 review). Subsequent studies recorded cell spiking rhythms learning closely resemble be (Otto 1991). It appears then sampling rates used intrinsic circuitries organize well suited activate chemical processes leading LTP. The nature linkages patterned cellular triggers been described 1986, 1988).