Interaction between paired-pulse facilitation and long-term potentiation of minimal excitatory postsynaptic potentials in rat hippocampal slices: A patch-clamp study

摘要: Long-term potentiation is an experimental paradigm used to study synaptic plasticity and memory mechanisms. One similarity between long-term the existence of several distinct phases. However, our preliminary quantal analysis did not reveal essential differences in expression mechanisms early ( 0.5-1 h) periods after tetanus. Calculations partial correlations regression indicated that positive correlation magnitude initial (pretetanic) paired-pulse facilitation tended increase late phase (1.5-2.5 h post-tetanus) indicating different are involved (0.5 potentiation. The findings compatible with involvement presynaptic both phases results suggest contribution changes release probability effective number transmitter sites may differ during two It suggested activation silent synapses increases transmission zones due pre- postsynaptic structural rearrangements represent important