Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition
作者： Valérie Lapointe , France Morin , Stéphanie Ratté , Ariane Croce , François Conquet
DOI: 10.1113/JPHYSIOL.2003.053603
关键词:
摘要: Hippocampal CA1 inhibitory interneurones control the excitability and synchronization of pyramidal cells, participate in hippocampal synaptic plasticity. Pairing theta-burst stimulation (TBS) with postsynaptic depolarization, we induced long-term potentiation (LTP) putative single-fibre excitatory currents (EPSCs) stratum oriens/alveus (O/A) mouse slices. LTP induction was absent metabotropic glutamate receptor 1 (mGluR1) knockout mice, correlated presence mGluR1a, required a Ca2+ rise. Changes paired-pulse facilitation coefficient variation indicated that expression involved presynaptic mechanisms. synapse specific, occurring selectively at synapses modulated by group II, but not III, mGluRs. Furthermore, TBS protocol applied O/A increase polysynaptic responses mGluR1 mice. These results uncover mechanisms novel form interneurone plasticity can adaptively regulate inhibition cells.
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