Novel process windows – Concept, proposition and evaluation methodology, and intensified superheated processing

摘要: The concept of novel process windows has recently been proposed by Hessel (2009) and his major processing variant, the pressurised superheated processing, is topic several recent reviews in field. Different from intensification micro-process technology enhancing mass heat transfer to reveal intrinsic kinetics, aim at speeding up i.e. dramatically reducing reaction time. This idea taken more technology, but origins as well encased practised since longer microwave organic chemistry. Novel highly intensified approach tends fully exploit kinetics (reactivity) while maintaining selectivity an acceptable level through use harsh conditions, rather than domesticate chemistry that common practice past. Reaction rates can be accelerated orders magnitude times shrink hours minutes seconds. accompanied large increase productivity a further cornerstone making competitive opposed economics scale, decades production aiming increasing vessel size more. content provided reviews, this compilation focuses on potential (while still providing short summary other options), methodology how find conditions evaluate these. Two reactions, Swern–Moffatt oxidation Claisen rearrangement, are discussed detail, these ideal candidates for high-temperature investigations due their eminent synthetic importance well-known kinetics. As practical example with industrial guidance running European Project, epoxidation vegetable oils, new exemplified beyond chemists’ descriptions given so far.