Diphenhydramine Derivatives: Through Manipulation toward Design

作者: A.F. Harms , W. Hespe , W.Th. Nauta , R.F. Rekker , H. Timmerman

DOI: 10.1016/B978-0-12-060306-0.50007-3

关键词: DiphenhydraminePharmacologyChemistry

摘要:

参考文章(65)
Anthony J. Glazko, Wesley A. Dill, Biochemical studies on diphenhydramine (benadryl) distribution in tissues and urinary excretion. Journal of Biological Chemistry. ,vol. 179, pp. 403- 408 ,(1949) , 10.1016/S0021-9258(18)56850-2
W. Hespe, H. Prins, W.F. Kafoe, W.Th. Nauta, Investigations into the metabolic fate and distribution of hepzidine maleate in the rat and the mouse. Biochemical Pharmacology. ,vol. 17, pp. 655- 666 ,(1968) , 10.1016/0006-2952(68)90002-6
M. Pailer, K. Nowotny, Zur Synthese des β-Aminoäthyl-benzhydryläthers und des N-Benzhydryl-aminoäthanols Monatshefte Fur Chemie. ,vol. 89, pp. 342- 345 ,(1958) , 10.1007/BF00898754
Victor F. Smolen, Misconceptions and Thermodynamic Untenability of Deviations from pH-Partition Hypothesis Journal of Pharmaceutical Sciences. ,vol. 62, pp. 77- 79 ,(1973) , 10.1002/JPS.2600620113
Josef Klosa, Eine neue Synthesemethode der Darstellung von Diarylalkylaminen Journal Fur Praktische Chemie-chemiker-zeitung. ,vol. 34, pp. 312- 334 ,(1966) , 10.1002/PRAC.19660340509
V. Mychajlyszyn, M. Protiva, Antihistamin-substanzen XLVI. Derivate des 2,3;6,7-dibenzosuberans Collection of Czechoslovak Chemical Communications. ,vol. 24, pp. 3955- 3965 ,(1959) , 10.1135/CCCC19593955
T. D. Perrine, Synthesis of compounds related to the methadols Journal of Organic Chemistry. ,vol. 18, pp. 898- 903 ,(1953) , 10.1021/JO50013A020
Thomas H. McGavack, Herbert Elias, Linn J. Boyd, Some pharmacological and clinical experiences with dimethylaminoethyl benzhydryl ether hydrochloride (benadryl). The American Journal of the Medical Sciences. ,vol. 213, pp. 418- 434 ,(1947) , 10.1097/00000441-194704000-00005
C. van Der Stelt, A. F. Harms, W. Th. Nauta, The effect of alkylsubstitution in drugs. V. Synthesis and chemical properties of some dibenzo [a,d]1,4-cycloheptadienyl ethers. Journal of Medicinal Chemistry. ,vol. 4, pp. 335- 349 ,(1961) , 10.1021/JM50018A008
Earl R. Loew, THE PHARMACOLOGY OF BENADRYL AND THE SPECIFICITY OF ANTIHISTAMINE DRUGS Annals of the New York Academy of Sciences. ,vol. 50, pp. 1142- 1160 ,(1950) , 10.1111/J.1749-6632.1950.TB39907.X