Retinoids Modulate Ara-CTP Pharmacology in the HL-60 Acute Leukemia Cell line
作者： C. Rössig , A. Freund , C. Lanvers , B. Hohenlöchter , M. Zühlsdorf
DOI: 10.1007/978-3-642-71960-8_85
关键词: In vivo 、 In vitro 、 Retinoid 、 Precursor cell 、 Intracellular 、 Pharmacology 、 Chemistry 、 Retinoic acid 、 Cell culture 、 Toxicity
摘要: Purpose To determine the ara-C-modulating efficacy of retinoids in leukemic blast cells. All-trans retinoic acid (ATRA) has been shown to increase sensitivity AML cells cytosine-arabinoside (ara-C). Ara-CTP accumulation is considered be main determinant ara-C toxicity vitro and vivo. To test hypothesis that exert their sensitizing effect by enhancing intracellular ara-CTP we studied ATRA 13-cis (13-cis RA) on ara-CTP-formation HL60 after 24 72 hours preincubation retinoid containing medium 1 hour exposure ara-C.
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