Emergence of fusarioses in a university hospital in Turkey during a 20-year period

摘要: Fusarium species have started appearing increasingly as the main cause of infections, particularly in immunocompromised patients. In this study, we aimed to present first epidemiological data from Turkey, analyze fusariosis cases that been monitored a university hospital during past 20 years, identify responsible species, and determine antifungal susceptibilities. A total 47 was included study. isolates were identified by multilocus sequence typing (MLST). Antifungal susceptibility tested broth microdilution method according Clinical Laboratory Standards Institute (CLSI) methodology. Of 23.4 % superficial, 44.7 locally invasive, 31.9 disseminated. significant increase observed over years. The fujikuroi complex (FFSC) proved be most frequent agent group (17 cases; 51.5 %), followed solani (FSSC) (14 42.4 dimerum (FDSC), oxysporum complexes (FOSC) (one case each). Amphotericin B had highest vitro activity against all species. Voriconazole posaconazole showed interspecies variability across within complexes. conclusion, our support fact regional differences exist distribution species-specific are patterns. monitoring local determining fungal identity importance guiding clinical follow-up