Reproductive factors and family history of breast cancer in relation to plasma prolactin levels in premenopausal and postmenopausal women.

摘要: Many reproductive factors are associated with breast cancer risk, potentially through a hormonal pathway. The peptide hormone prolactin is essential in mammary development and lactation may be link between risk cancer. While higher levels increased few determinants of known. We conducted cross-sectional analysis among 1,089 premenopausal 1,311 postmenopausal women within the Nurses' Health Study (NHS) NHS II to examine associations factors, benign disease family history plasma levels. Parous had significantly lower than nulliparous (parous vs. multivariate-adjusted geometric means = 14.1 ng/mL 16.6 ng/mL, p < 0.001 for 9.1 10.1, 0.04 women), although did not decrease increasing number children either (p-trend 0.23) or 0.07) parous women. Age at first birth was reduction appeared attenuate time since birth, but trend statistically significant 0.12). menarche, duration were Family when compared no (15.9 14.3 0.04) (p 0.73) In conclusion, parity mediated, least part, by © 2006 Wiley-Liss, Inc.