Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity.

摘要: Breast cancer (BC) remains a leading cause of death among women today, and mortality African American in the US 40% higher than that their White counterparts, despite reporting similar incidence disease over recent years. Previous meta-analyses studies BC highlight tumor characteristics, rather socio-economic factors, drive excess with BC. This is further complicated by heterogeneity BC, where can more appropriately be defined as collection diseases single disease. Molecular phenotyping gene expression profiling distinguish subtypes these have distinct prognostic outcomes. Racial disparities transcend subtype-specific outcomes, suffer rates all subtypes. The most striking differences are observed aggressive molecular subtype, triple-negative (TNBC), significantly compared to other race/ethnicity groups. We others shown this predisposition for may linked shared west ancestry, highest TNBC nations, high frequencies follow into diaspora. Genetic characterization breast tumors racial/ethnic groups begun identify targets future therapeutic potential, but work needs done targeted treatment options who from