Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor.
作者： LiMei Wang , Jennifer J Rahn , XueQing Lun , Beichen Sun , John J. P Kelly
DOI: 10.1371/JOURNAL.PBIO.0060289
关键词: Low-affinity nerve growth factor receptor 、 Brain tumor 、 Cancer research 、 Biology 、 Amyloid precursor protein secretase 、 Gamma secretase 、 Immunology 、 Cell surface receptor 、 Nerve growth factor 、 Glioma 、 Receptor
摘要: … Using an intracranial glioma model, we assessed the therapeutic potential of γ-secretase inhibitors. Parallel experiments were performed using the genetically distinct U87p75 NTR and …
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