Compositions and Methods for the Treatment of Radioresistant Glioma Stem Cells

作者: Bruce A. Sullenger , Jeremy N. Rich , Jialiang Wang

DOI:

关键词:

摘要: Compositions and uses of gamma secretase inhibitors (GSIs) for the treatment inhibition gliomas in subjects need thereof are provided. Methods administering association with radiation resistant described. Notch signaling activity

参考文章(12)
Annick, Desjardins, Chemotherapy and novel therapeutic approaches in malignant gliomas Frontiers in Bioscience. ,vol. 10, pp. 2645- 2668 ,(2005) , 10.2741/1727
Anirban Maitra, Charles Eberhart, Xing Fan, Cancer treatment with gama-secretase inhibitors ,(2007)
H. F. Dovey, V. John, J. P. Anderson, L. Z. Chen, P. De Saint Andrieu, L. Y. Fang, S. B. Freedman, B. Folmer, E. Goldbach, E. J. Holsztynska, K. L. Hu, K. L. Johnson-Wood, S. L. Kennedy, D. Kholodenko, J. E. Knops, L. H. Latimer, M. Lee, Z. Liao, I. M. Lieberburg, R. N. Motter, L. C. Mutter, J. Nietz, K. P. Quinn, K. L. Sacchi, P. A. Seubert, G. M. Shopp, E. D. Thorsett, J. S. Tung, J. Wu, S. Yang, C. T. Yin, D. B. Schenk, P. C. May, L. D. Altstiel, M. H. Bender, L. N. Boggs, T. C. Britton, J. C. Clemens, D. L. Czilli, D. K. Dieckman-McGinty, J. J. Droste, K. S. Fuson, B. D. Gitter, P. A. Hyslop, E. M. Johnstone, W-Y. Li, S. P. Little, T. E. Mabry, F. D. Miller, B. Ni, J. S. Nissen, W. J. Porter, B. D. Potts, J. K. Reel, D. Stephenson, Y. Su, L. A. Shipley, C. A. Whitesitt, T. Yin, J. E. Audia, Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain Journal of Neurochemistry. ,vol. 76, pp. 173- 181 ,(2009) , 10.1046/J.1471-4159.2001.00012.X
LiMei Wang, Jennifer J Rahn, XueQing Lun, Beichen Sun, John J. P Kelly, Samuel Weiss, Stephen M Robbins, Peter A Forsyth, Donna L Senger, Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. PLOS Biology. ,vol. 6, ,(2008) , 10.1371/JOURNAL.PBIO.0060289
Raymond J. Winquist, Diane M. Boucher, Mark Wood, Brinley F. Furey, Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine. Biochemical Pharmacology. ,vol. 78, pp. 326- 334 ,(2009) , 10.1016/J.BCP.2009.03.020
Xing Fan, Leila Khaki, Thant S. Zhu, Mary E. Soules, Caroline E. Talsma, Naheed Gul, Cheryl Koh, Jiangyang Zhang, Yue-Ming Li, Jarek Maciaczyk, Guido Nikkhah, Francesco DiMeco, Sara Piccirillo, Angelo L. Vescovi, Charles G. Eberhart, NOTCH Pathway Blockade Depletes CD133‐Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts Stem Cells. ,vol. 28, pp. 5- 16 ,(2009) , 10.1002/STEM.254
Jun Lin, Xing-Mei Zhang, Jin-Cheng Yang, Yong-Bin Ye, Shen-Qiu Luo, γ-Secretase Inhibitor-I Enhances Radiosensitivity of Glioblastoma Cell Lines by Depleting CD133+ Tumor Cells Archives of Medical Research. ,vol. 41, pp. 519- 529 ,(2010) , 10.1016/J.ARCMED.2010.10.006
Andrea Geling, Harald Steiner, Michael Willem, Laure Bally‐Cuif, Christian Haass, A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish EMBO Reports. ,vol. 3, pp. 688- 694 ,(2002) , 10.1093/EMBO-REPORTS/KVF124
Jialiang Wang, Timothy P. Wakeman, Justin D. Lathia, Anita B. Hjelmeland, Xiao-Fan Wang, Rebekah R. White, Jeremy N. Rich, Bruce A. Sullenger, Notch promotes radioresistance of glioma stem cells Stem Cells. ,vol. 28, pp. 17- 28 ,(2009) , 10.1002/STEM.261