Adeno-associated virus variants and methods of use thereof

摘要: The present disclosure provides infectious recombinant adeno-associated virus (rAAV) virions that comprise a variant capsid protein and heterologous nucleic acid. further the (AAV) proteins (and/or acid encoding AAV proteins), which confer to an rAAV virion increased resistance human neutralizing antibodies. host cells comprising and/or subject protein. methods of delivering target cell where is contacted with virion. gene product individual, generally involving administering effective amount individual in need thereof.