MUTANT OF ADENO-ASSOCIATED VIRUS (AAV) CAPSID PROTEIN
作者： Kinoh Hiromi , Enoki Tatsuji , Nishie Toshikazu , Okada Hironori , Okada Takashi
DOI:
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摘要: The present invention provides: a mutant of adeno-associated virus (AAV) capsid protein, which contains at least one amino acid substitution in PLA2 domain when compared with the sequence for wild-type AAV and occurs position selected from group consisting (1) an alanine residue position-3, (2) tyrosine position-6, (3) position-68, (4) aspartic position-87, (5) leucine position-91, (6) serine position-149, (7) proline position-150 (8) position-156 AAV2 VP1 protein or positions corresponding to above-mentioned other than AAV2; nucleic encoding mutant; cell containing acid; method producing recombinant particle, comprising step culturing produce particle; particle composition transferring gene into target cell, bringing contact cell.
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