A REEVALUATION OF THE THRESHOLD EXPOSURE LEVEL OF INHALED JP-8 IN MICE

摘要: C57BL/6 mice were nose-only exposed to JP-8 jet fuel at average concentrations of 45, 267, and 406 mg JP-8/m3 for 1 hr/d 7 days further test the hypothesis that exposure below current permissible level (PEL) 350 mg/m3 will induce lung injury, validate a new "in-line, real-time" total hydrocarbon analysis system capable measuring both vapor aerosol concentrations. Pulmonary function respiratory permeability tests performed 24 30 hr after final exposures. No significant effects observed 45 or 267 mg/m3. The only effect was decrease in inspiratory dynamic compliance. Morphological examination morphometric distal tissue demonstrated alveolar type II epithelial cells showed limited cellular damage with notable exception increase volume density lamellar bodies (vacuoles), which is indicative increased surfactant production, terminal bronchial epithelium initial signs damage, but did not quantify these changes as significant. techniques appear provide an sensitivity detecting deleterious compared physiological evidence offered by pulmonary tests. These observations suggest PEL other more volatile petroleum distillates should be reevaluated lower, accurate established regard human occupational limits.